| 2008 Regular Season | |||
| Date | Time | Opponent | TV/Score |
| Sun., September 7 | 1:15 PM | CAROLINA | 26-24 L |
| Sun., September 14 | 1:15 PM | @ Denver | 39-38 L |
| Mon., September 22 | 5:30 PM | NY JETS (Buy Now!) | 29-48 W |
| Sun., September 28 | 1:05 PM | @ Oakland | CBS |
| Sun., October 5 | 10:00 AM | @ Miami | CBS |
| Sun., October 12 | 5:15 PM | NEW ENGLAND (Buy Now!) | NBC |
| Sun., October 19 | 10:00 am | @ Buffalo | CBS |
| Sun., October 26 | 10:00 am | @ New Orleans (London) | CBS |
| Sun., November 2 | BYE | ||
| Sun., November 9 | 1:15 pm | KANSAS CITY (Buy Now!) | CBS |
| Sun., November 16 | 1:15 pm* | @ Pittsburgh | CBS |
| Sun., November 23 | 5:15 pm* | INDIANAPOLIS (Buy Now!) | NBC |
| Sun., November 30 | 1:05 pm* | ATLANTA (Buy Now!) | FOX |
| Thrs., December 4 | 5:15 PM | OAKLAND (Buy Now!) | NFLN |
| Sun., December 14 | 10:00 am* | @ Kansas City | CBS |
| Sun., December 21 | 5:15 pm* | @ Tampa Bay | NBC |
| Sun., December 28 | 1:15 pm* | DENVER (Buy Now!) | CBS |
| BOLD = home games *Time subject to change due to flexible scheduling | |||
